Pd(II)-Catalyzed Directing-Group-Aided C–H Arylation and Alkylation of Pyrene Core: Synthesis of C1,C2- and C1,C10-Disubstituted Pyrene Motifs

Abstract We report the application of Pd(II)-catalyzed, directing-group-aided C–H arylation/alkylation tactics to functionalize pyrene core, especially, relatively inaccessible C2 and K-region C10 positions core augmentation library derivatives with C1,C2- C1,C10-disubstituted motifs. The Pd(II)-catalyzed β-C–H C2-position pyrene-1-carboxamide possessing an 8-aminoquinoline directing group yielded various C1,C2-disubstituted pyrenes. Similarly, selective γ-C–H C10-position N-(pyren-1-yl)picolinamide, a picolinamide group, Examples C(9)–H arylation removal after reactions were also shown. structures representative confirmed by X-ray structure analysis. Given importance in fields chemical sciences, this is contribution towards amide